Serum carnitine analysis is useful in the diagnosis and monitoring of patients with carnitine deficiency (either primary or secondary). Primary carnitine deficiency is an autosomal recessively inherited genetic condition that affects carnitine uptake by cells and tissues through a defect in the plasma membrane carnitine transporter. Secondary carnitine deficiency can be seen in some disease states or in patients on carnitine-poor diets, but is also seen in a number of metabolic disorders. In these disorders, carnitine complexes with the accumulated substrate of the blocked metabolic step, and the resulting acylcarnitine ester is excreted in the urine, leading to a depletion of carnitine in the patient.
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- Fasting Required: NO
- Preferred Specimen: Serum
- Test Includes: Carnitine, Total; Carnitine, Free; Carnitine, Esters; Esterified/Free Ratio
- Reference Range(s):
Carnitine, Total Adult Male 30-70 µmol/L Adult Female 25-58 µmol/L Male ≤17 Years 32-62 µmol/L Female ≤17 Years 28-59 µmol/L Female ≤17 Years 28-59 µmol/L Carnitine, Free Adult Male 23-59 µmol/L Adult Female 19-48 µmol/L Male ≤17 Years 25-54 µmol/L Female ≤17 Years 19-51 µmol/L Carnitine, Esters Adult Male 4-15 µmol/L Adult Female 4-13 µmol/L Male ≤17 Years 4-12 µmol/L Female ≤17 Years 3-16 µmol/L Esterified/Free Ratio Adult Male 0.12-0.39 Adult Female 0.13-0.42 Male ≤17 Years 0.09-0.35 Female ≤17 Years 0.09-0.49
- Patient Prep: Patient should be in a well-fed state
- Turnaround Time: 3 Days
- Test Code: 70107