Celiac Disease Comprehensive Panel


Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.

Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.

The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results

Celiac Disease Comprehensive Panel


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  • Fasting Required: NO
  • Preferred Specimen: Serum
  • Test Includes: Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex
  • Reference Range(s):
    (tTG) Antibody, (IgA)  
    <4 U/mL No antibody detected
    4 U/mL Antibody detected
    IgA, Serum  
    Cord Blood 1-3 mg/dL
    1 Month 2-43 mg/dL
    2-5 Months 3-66 mg/dL
    6-9 Months 7-66 mg/dL
    10-12 Months 12-75 mg/dL
    1-3 Years 24-121 mg/dL
    4-6 Years 33-235 mg/dL
    7-9 Years 41-368 mg/dL
    10-11 Years 64-246 mg/dL
    12-13 Years 70-432 mg/dL
    14-15 Years 57-300 mg/dL
    ≥16 Years 81-463 mg/dL
  • Turnaround Time: 3 Days
  • Test Code: 19955