Collagen Cross-Linked N-Telopeptide NTx



The Collagen Cross-Linked N-Telopeptide urine test is commonly used to assess bone resorption in patients with metabolic bone disease. The Collagen Cross-Linked N-Telopeptide (NTx) urine test is a medical test used to measure the level of NTx in the urine. NTx is a breakdown product of collagen, which is a major component of bone tissue.  Bone resorption is a normal part of the bone remodeling process, where old or damaged bone is broken down and replaced with new bone tissue. However, excessive bone resorption can lead to bone loss and osteoporosis, a condition characterized by weak and brittle bones.

The Collagen Cross-Linked N-Telopeptide test is commonly used in the following situations:

Osteoporosis Assessment: It is used to assess bone turnover in individuals with osteoporosis or those at risk of developing osteoporosis. Osteoporosis is a condition where bone density decreases, leading to an increased risk of fractures.

Monitoring Treatment Efficacy: For individuals undergoing treatment for osteoporosis or other bone-related conditions, the NTx test can be used to monitor the response to therapy. A decrease in NTx levels may indicate that the treatment is effective in reducing bone resorption.

Fracture Risk Prediction: The test can help estimate an individual's risk of future fractures by measuring the level of bone turnover in the body.

Assessment of Bone Health: The NTx test may be used as part of a comprehensive assessment of bone health, along with other bone turnover markers and bone mineral density tests.

Collagen Cross-Linked N-Telopeptide NTx


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Reference Range(s)

Collagen Cross-Linked N-Telopeptide (NTx), Random Urine



  18-29 Years

12-99 nM BCE/mM creat

  30-59 Years

9-60 nM BCE/mM creat




4-64 nM BCE/mM creat

Results are primarily used for monitoring the response to therapy. A value within the premenopausal reference range does not rule out osteoporosis nor the need for therapy.

Creatinine, Random Urine

≤6 Months

2-28 mg/dL

7-11 Months

2-31 mg/dL

1-2 Years

2-110 mg/dL

3-8 Years

2-130 mg/dL

9-12 Years

2-160 mg/dL

>12 Years Male

20-320 mg/dL

>12 Years Female

20-275 mg/dL


Fasting Required: No

Turnaround Time: 3 Days

Test Code: 36167

Preferred Specimen: Urine