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Testing Details

The ANA Screen IFA with Reflex to Titer and Pattern is a diagnostic blood test used to detect antinuclear antibodies (ANA) in the blood — a key marker for autoimmune disorders. These antibodies can signal that the immune system is attacking the body’s own cells, a hallmark of diseases like lupus, rheumatoid arthritis, and scleroderma.

Why Order an ANA IFA Test?

Doctors often order this test when a patient presents with symptoms such as joint pain, fatigue, rashes, or unexplained fevers. A positive ANA result may lead to further testing to identify specific autoimmune diseases.

Reflex to Titer and Pattern

If the initial screen is positive, the test reflexes to a titer (which measures concentration) and a pattern (which helps narrow down the possible autoimmune condition). For example:

• A homogeneous pattern may suggest lupus.
• A speckled pattern may indicate Sjogren’s syndrome.
• A nucleolar pattern may point to scleroderma.
• A centromere pattern may suggest CREST syndrome.
• Tracking Disease Activity

ANA titers can also help assess disease activity. Higher titers often reflect a more active disease, while declining titers may indicate successful treatment.

Part of a Broader Workup

This test is often used alongside other labs and clinical assessments when autoimmune disease is suspected. Its combination of early detection, specificity, and reflex features makes it a reliable tool in both diagnosis and monitoring.

Importance

The ANA Screen IFA with Reflex to Titer and Pattern plays a critical role in identifying autoimmune disorders early, guiding accurate diagnoses, and monitoring progression or treatment response. It is especially useful for patients with vague symptoms that require a broader diagnostic approach.